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Rekombinanter MTAP Antikörper (AA 97-196)

MTAP Reaktivität: Human IHC, StM, ISt Wirt: Maus Monoclonal rMTAP-1813 unconjugated Recombinant Antibody
Produktnummer ABIN6940088
  • Target Alle MTAP Antikörper anzeigen
    MTAP (Methylthioadenosine phosphorylase (MTAP))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 14
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 97-196
    Reaktivität
    • 54
    • 13
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 49
    • 7
    Maus
    Klonalität
    • 45
    • 11
    Monoklonal
    Konjugat
    • 33
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTAP Antikörper ist unkonjugiert
    Applikation
    • 43
    • 32
    • 12
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM), Immunostaining (ISt)
    Spezifität
    Recognizes a protein of 31 kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
    Klon
    RMTAP-1813
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product MTAP Primärantikörper
  • Applikationshinweise

    Positive Control: HepG2, A431, HeLa or MCF-7 cells. Human kidney tissues (IHC).

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    MTAP (Methylthioadenosine phosphorylase (MTAP))
    Andere Bezeichnung
    MTAP (MTAP Produkte)
    Synonyme
    BDMF antikoerper, DMSFH antikoerper, DMSMFH antikoerper, LGMBF antikoerper, MSAP antikoerper, c86fus antikoerper, Cc1-6 antikoerper, 1300019I21Rik antikoerper, MTAPase antikoerper, zgc:66012 antikoerper, mtap antikoerper, methylthioadenosine phosphorylase antikoerper, 5'-methylthioadenosine phosphorylase antikoerper, 6-oxopurine nucleoside phosphorylase antikoerper, methylthioadenosine phosphorylase L homeolog antikoerper, MTAP antikoerper, Mtap antikoerper, mtaP antikoerper, MMAH_RS04260 antikoerper, TAGG_RS05050 antikoerper, Toce_0364 antikoerper, VDIS_RS03165 antikoerper, MFER_RS02485 antikoerper, Intca_0886 antikoerper, DESMU_RS05370 antikoerper, Dester_1490 antikoerper, ARCVE_RS05445 antikoerper, Mahau_1873 antikoerper, MZHIL_RS01440 antikoerper, mtap antikoerper, mtap.L antikoerper
    Molekulargewicht
    31kDa
    Gen-ID
    4507
    UniProt
    Q13126
    Pathways
    Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process
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