NGFR Antikörper (AA 281-421)

Produktnummer ABIN6940196

Produktdetails anti-NGFR Antikörper

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Bindungsspezifität: AA 281-421

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NGFR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Differentiation (Diff), Staining Methods (StM)

Spezifität: It recognizes a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human p75 NGFR protein (around aa 281-421) (exact sequence is proprietary)

Klon: NGFR-1964

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Neuronal axons, Schwann cells and perineural cells of peripheral nerves or tumors of nerve sheath differentiation e. G. Schwannoma, Neurofibroma. Soma and axons of sensory neurons and ganglionic satellite cells. Melanomas.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Andere Bezeichnung: NGFR (NGFR Produkte)

Synonyme: ngfr antikoerper, wu:fb38c02 antikoerper, wu:fc10h01 antikoerper, CD271 antikoerper, Gp80-LNGFR antikoerper, TNFRSF16 antikoerper, p75(NTR) antikoerper, p75NTR antikoerper, LNGFR antikoerper, RNNGFRR antikoerper, Tnfrsf16 antikoerper, p75 antikoerper, NRH1b antikoerper, fullback antikoerper, nrh1 antikoerper, p75ntr antikoerper, tnfrsf16 antikoerper, p75NGFR antikoerper, nerve growth factor receptor antikoerper, neurotrophin receptor associated death domain antikoerper, nerve growth factor receptor S homeolog antikoerper, nerve growth factor receptor (TNFR superfamily, member 16) antikoerper, NGFR antikoerper, nradd antikoerper, Ngfr antikoerper, ngfr.S antikoerper

Molekulargewicht: 75kDa

Gen-ID: 4804

UniProt: P08138

Pathways: NF-kappaB Signalweg, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding