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NKX3-1 Antikörper (AA 92-224)

NKX3-1 Reaktivität: Human ELISA, IHC, Coat, StM Wirt: Maus Monoclonal NKX3-1-2576 unconjugated
Produktnummer ABIN6940209
  • Target Alle NKX3-1 Antikörper anzeigen
    NKX3-1 (NK3 Homeobox 1 (NKX3-1))
    Bindungsspezifität
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 92-224
    Reaktivität
    • 70
    • 19
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 57
    • 22
    • 1
    Maus
    Klonalität
    • 56
    • 24
    Monoklonal
    Konjugat
    • 46
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser NKX3-1 Antikörper ist unkonjugiert
    Applikation
    • 57
    • 44
    • 14
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Coating (Coat), Staining Methods (StM)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant fragment (around aa 92-224) of human NKX3.1 protein (exact sequence is proprietary)
    Klon
    NKX3-1-2576
    Isotyp
    IgG2c kappa
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    Discover our top product NKX3-1 Primärantikörper
  • Applikationshinweise

    Positive Control: Highly expressed in the prostate and at a lower level in the testis.

    Known Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    NKX3-1 (NK3 Homeobox 1 (NKX3-1))
    Andere Bezeichnung
    NKX3-1 (NKX3-1 Produkte)
    Synonyme
    Xbagpipe antikoerper, Xbap antikoerper, bagpipe antikoerper, koza antikoerper, nkx3-1 antikoerper, nkx3.1 antikoerper, si:ch211-67o1.2 antikoerper, nkx3a antikoerper, MGC53041 antikoerper, MGC97890 antikoerper, Bax antikoerper, NKX3.1 antikoerper, NKX3A antikoerper, Nkx-3.1 antikoerper, BAPX2 antikoerper, NKX3 antikoerper, NK3 homeobox 1 L homeolog antikoerper, NK3 homeobox 1 antikoerper, NK-3 transcription factor, locus 1 (Drosophila) antikoerper, nkx3-1.L antikoerper, NKX3-1 antikoerper, nkx3-1 antikoerper, Nkx3-1 antikoerper
    Hintergrund
    NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
    Molekulargewicht
    35kDa
    Gen-ID
    4824
    UniProt
    Q99801
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus
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