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PAPPA Antikörper (AA 351-523)

PAPPA Reaktivität: Human IHC, StM Wirt: Maus Monoclonal PAPPA-2715 unconjugated
Produktnummer ABIN6940248
  • Target Alle PAPPA Antikörper anzeigen
    PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
    Bindungsspezifität
    • 15
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-523
    Reaktivität
    • 86
    • 22
    Human
    Wirt
    • 46
    • 45
    • 1
    Maus
    Klonalität
    • 46
    • 46
    Monoklonal
    Konjugat
    • 31
    • 14
    • 11
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PAPPA Antikörper ist unkonjugiert
    Applikation
    • 49
    • 46
    • 29
    • 18
    • 13
    • 13
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
    Klon
    PAPPA-2715
    Isotyp
    IgG2b kappa
  • Applikationshinweise

    Positive Control: Placenta.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
    Andere Bezeichnung
    PAPPA (PAPPA Produkte)
    Synonyme
    8430414N03Rik antikoerper, IGFBP-4ase antikoerper, PAG1 antikoerper, PAPP-A antikoerper, ASBABP2 antikoerper, DIPLA1 antikoerper, PAPA antikoerper, PAPPA1 antikoerper, Pappa antikoerper, pappalysin 1 antikoerper, pregnancy-associated plasma protein A antikoerper, PAPPA antikoerper, Pappa antikoerper, Pappa1 antikoerper
    Molekulargewicht
    181kDa
    Gen-ID
    5069
    UniProt
    Q13219
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