PAX2A Antikörper (AA 223-354)

Produktnummer ABIN6940252

Produktdetails anti-PAX2A Antikörper

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Bindungsspezifität: AA 223-354

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAX2A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Coating (Coat), Staining Methods (StM)

Spezifität: Recognizes a protein of 42 kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 223-354) human PAX2 protein (exact sequence is proprietary)

Klon: PAX2-1104

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: NAMALWA cells. Fetal kidney or Renal Cell Carcinoma (RCC) or Ovarian Carcinoma.

Known Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PAX2A

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Andere Bezeichnung: PAX2 (PAX2A Produkte)

Synonyme: PAPRS antikoerper, Opdc antikoerper, Pax-2 antikoerper, Pax-2a antikoerper, XPax-2 antikoerper, XPax2 antikoerper, pax-2 antikoerper, pax2 antikoerper, xPax-2a antikoerper, PAXZF-B antikoerper, cb378 antikoerper, noi antikoerper, pax-b antikoerper, pax2.1 antikoerper, pax2a1 antikoerper, pax[zf-b] antikoerper, paxb antikoerper, pax2.2 antikoerper, paired box 2 antikoerper, paired box 2 L homeolog antikoerper, paired box 2a antikoerper, paired box 2b antikoerper, PAX2 antikoerper, Pax2 antikoerper, pax2.L antikoerper, pax2a antikoerper, pax2b antikoerper

Molekulargewicht: 42kDa

Gen-ID: 5076

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation