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Rekombinanter Cytochrome C Antikörper (AA 1-80)

CYCS Reaktivität: Human, Ratte, Maus, Pferd, Hund, Taube, Drosophila melanogaster, Frosch IHC, StM Wirt: Maus Monoclonal rCYCS-1010 unconjugated Recombinant Antibody
Produktnummer ABIN6940324
  • Target Alle Cytochrome C (CYCS) Antikörper anzeigen
    Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 16
    • 12
    • 10
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-80
    Reaktivität
    • 145
    • 119
    • 98
    • 44
    • 31
    • 22
    • 21
    • 19
    • 17
    • 15
    • 7
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Pferd, Hund, Taube, Drosophila melanogaster, Frosch
    Wirt
    • 85
    • 75
    • 6
    • 1
    Maus
    Klonalität
    • 84
    • 82
    • 1
    Monoklonal
    Konjugat
    • 96
    • 13
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cytochrome C Antikörper ist unkonjugiert
    Applikation
    • 128
    • 51
    • 38
    • 36
    • 32
    • 31
    • 27
    • 21
    • 14
    • 13
    • 13
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    It recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Synthetic peptides corresponding to amino acid 1-80, 81-104 and 66-104 of pigeon cytochrome c
    Klon
    RCYCS-1010
    Isotyp
    IgG1 kappa
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  • Applikationshinweise

    Positive Control: K-562, HL-60, Jurkat, NIH3T3 or PC-3 cells. Liver or Cardiac muscle.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
    Andere Bezeichnung
    CYCS (CYCS Produkte)
    Synonyme
    CYC antikoerper, HCS antikoerper, THC4 antikoerper, cyct antikoerper, cyc antikoerper, hcs antikoerper, CYCS antikoerper, cytc antikoerper, CYCSA antikoerper, CG17903 antikoerper, Cyt C antikoerper, Cyt c antikoerper, Cyt-c2 antikoerper, CytC-2 antikoerper, Cytc antikoerper, Cytc-p antikoerper, DC4 antikoerper, DMc01 antikoerper, Dmel\\CG17903 antikoerper, cyt c antikoerper, cyt c-p antikoerper, cyt-c-p antikoerper, cyt-c2 antikoerper, cyt.c antikoerper, cytochrome c antikoerper, dc4 antikoerper, pDMc01 antikoerper, wu:fk52b01 antikoerper, zgc:86706 antikoerper, ENSMUSG00000058927 antikoerper, cytochrome c, somatic antikoerper, cytochrome c, somatic S homeolog antikoerper, Cytochrome c proximal antikoerper, cytochrome c, somatic b antikoerper, cytochrome c, somatic pseudogene antikoerper, cytochrome c-like antikoerper, cytochrome c antikoerper, CYCS antikoerper, cycs.S antikoerper, cycs antikoerper, Cycs antikoerper, Cyt-c-p antikoerper, cycsb antikoerper, Gm10053 antikoerper, LOC100724240 antikoerper, CYC antikoerper, LOC100847700 antikoerper, LOC101107954 antikoerper, LOC106829744 antikoerper, LOC106992390 antikoerper, LOC102085712 antikoerper
    Molekulargewicht
    15kDa
    Gen-ID
    54205
    UniProt
    P99999
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
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