EGLN1 Antikörper (AA 1-24)
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- Target Alle EGLN1 Antikörper anzeigen
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
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Bindungsspezifität
- AA 1-24
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser EGLN1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Residues 1-24 of PHD2
- Klon
- 366G-76-3
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product EGLN1 Primärantikörper
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- Applikationshinweise
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Positive Control: MCF7 cells. Brain or adrenal gland.
Known Application: Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
- Andere Bezeichnung
- EGLN1 (EGLN1 Produkte)
- Synonyme
- EGLN1 antikoerper, egln2 antikoerper, phd2 antikoerper, zgc:92314 antikoerper, AI503754 antikoerper, C1orf12 antikoerper, HIF-PH2 antikoerper, HPH-2 antikoerper, Hif-p4h-2 antikoerper, ORF13 antikoerper, Phd2 antikoerper, SM-20 antikoerper, PHD-2 antikoerper, PHD2 antikoerper, ECYT3 antikoerper, HIFPH2 antikoerper, HPH2 antikoerper, SM20 antikoerper, ZMYND6 antikoerper, egl nine homolog 1 (C. elegans) antikoerper, egl-9 family hypoxia inducible factor 1 antikoerper, egl-9 family hypoxia-inducible factor 1 S homeolog antikoerper, egl-9 family hypoxia-inducible factor 1b antikoerper, egl-9 family hypoxia-inducible factor 1 antikoerper, EGLN1 antikoerper, egln1.S antikoerper, egln1b antikoerper, Egln1 antikoerper
- Hintergrund
- 366G/76/3 recognises human prolyl hydroxylase 2 (PHD2), a 46 kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
- Molekulargewicht
- 46kDa
- Gen-ID
- 54583
- UniProt
- Q9GZT9
- Pathways
- cAMP Metabolic Process, Warburg Effekt
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