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PPP3CA Antikörper

PPP3CA Reaktivität: Human IHC, StM Wirt: Maus Monoclonal CALNA-2353 unconjugated
Produktnummer ABIN6940381
  • Target Alle PPP3CA Antikörper anzeigen
    PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
    Reaktivität
    • 59
    • 31
    • 28
    • 14
    • 10
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 47
    • 11
    • 2
    Maus
    Klonalität
    • 48
    • 12
    Monoklonal
    Konjugat
    • 41
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPP3CA Antikörper ist unkonjugiert
    Applikation
    • 48
    • 20
    • 14
    • 10
    • 10
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human Calcineurin A protein
    Klon
    CALNA-2353
    Isotyp
    IgG1 kappa
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  • Applikationshinweise

    Positive Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
    Andere Bezeichnung
    Calcineurin A / PPP3CA (PPP3CA Produkte)
    Synonyme
    CALN antikoerper, CALNA antikoerper, CALNA1 antikoerper, CCN1 antikoerper, CNA1 antikoerper, PPP2B antikoerper, 2900074D19Rik antikoerper, AI841391 antikoerper, AW413465 antikoerper, CN antikoerper, Caln antikoerper, Calna antikoerper, CnA antikoerper, Calna1 antikoerper, calcineurin antikoerper, caln antikoerper, calna antikoerper, calna1 antikoerper, ccn1 antikoerper, cna1 antikoerper, ppp2b antikoerper, fj46e08 antikoerper, si:dkeyp-79c2.2 antikoerper, wu:fj46e08 antikoerper, ppp3ca antikoerper, protein phosphatase 3 catalytic subunit alpha antikoerper, protein phosphatase 3, catalytic subunit, alpha isoform antikoerper, protein phosphatase 3, catalytic subunit, alpha isozyme antikoerper, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) antikoerper, protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog antikoerper, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antikoerper, PPP3CA antikoerper, Ppp3ca antikoerper, ppp3ca antikoerper, ppp3ca.L antikoerper, LOC100205420 antikoerper
    Hintergrund
    Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
    Molekulargewicht
    62kDa
    Gen-ID
    5530
    UniProt
    Q08209
    Pathways
    RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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