PPP3R1 Antikörper

Produktnummer ABIN6940383

Produktdetails anti-PPP3R1 Antikörper

Target: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Reaktivität: Human, Xenopus laevis

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPP3R1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Staining Methods (StM), Coating (Coat)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length human Calcineurin B protein

Klon: BE2-1

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: HeLa, MCF-7 or A431 cells. Human brain, breast or stomach tissue.

Known Application: ELISA (For coating, order antibody without BSA), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PPP3R1

Target: PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))

Andere Bezeichnung: PPP3R1 (PPP3R1 Produkte)

Synonyme: si:ch211-274c22.8 antikoerper, canb antikoerper, CALNB1 antikoerper, CNB antikoerper, CNB1 antikoerper, CaNB1 antikoerper, Cnb1 antikoerper, MCIP1 antikoerper, protein phosphatase 3, regulatory subunit B, alpha a antikoerper, protein phosphatase 3 regulatory subunit B, alpha S homeolog antikoerper, protein phosphatase 3 regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha antikoerper, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) antikoerper, ppp3r1a antikoerper, ppp3r1.S antikoerper, PPP3R1 antikoerper, Ppp3r1 antikoerper

Hintergrund: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Molekulargewicht: 19kDa

Gen-ID: 5534

UniProt: P63098

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling