Rekombinanter PTH Antikörper (AA 1-34)

Produktnummer ABIN6940427

Produktdetails anti-PTH Antikörper

Target: PTH (Parathyroid Hormone (PTH))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: AA 1-34

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PTH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Spezifität: Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Kreuzreaktivität (Details): Predicted to react with Mouse. Rat. Rabbit. Cow. Dog. Pig. Deer. Orangutan.

Immunogen: A synthetic peptide around amino acids 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary)

Klon: RPTH-911

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human parathyroid gland carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed. Not suitable for frozen tissues.) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PTH

Target: PTH (Parathyroid Hormone (PTH))

Andere Bezeichnung: PTH (PTH Produkte)

Synonyme: PTH1 antikoerper, Pthp antikoerper, PTH-(1-84) antikoerper, Pth1 antikoerper, Pthr1 antikoerper, PTH antikoerper, parathyroid hormone antikoerper, parathyroid hormone S homeolog antikoerper, PTH antikoerper, Pth antikoerper, pth.S antikoerper

Substanzklasse: Hormone

Molekulargewicht: 9kDa

Gen-ID: 5741

UniProt: P01270

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process