Melanoma gp100 Antikörper (AA 376-502)
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- Target Alle Melanoma gp100 (PMEL) Antikörper anzeigen
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
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Bindungsspezifität
- AA 376-502
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Melanoma gp100 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), ELISA, Staining Methods (StM), Coating (Coat)
- Immunogen
- A recombinant fragment (around aa 376-502) of human SILV protein (exact sequence is proprietary)
- Klon
- PMEL-2037
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product PMEL Primärantikörper
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anti-Premelanosome Protein (PMEL) antibody
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anti-Premelanosome Protein (PMEL) (AA 1-661) antibodyPMEL Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Positive Control: SK-MEL-28 cells. Melanoma.
Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
- Andere Bezeichnung
- SILV (PMEL Produkte)
- Hintergrund
- Cytotoxic T lymphocytes (CTL s) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.
- Molekulargewicht
- 90-100kDa
- Gen-ID
- 6490
- UniProt
- P40967
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