STAT5B Antikörper
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- Target Alle STAT5B Antikörper anzeigen
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser STAT5B Antikörper ist unkonjugiert
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Applikation
- ELISA, Coating (Coat)
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Recombinant full-length human STAT5B protein
- Klon
- STAT5B-2657
- Isotyp
- IgG
- Top Product
- Discover our top product STAT5B Primärantikörper
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- Applikationshinweise
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Positive Control: Human spleen.
Known Application: ELISA (For coating use Ab at 1-5 μg/mL, order Ab without BSA) Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
- Andere Bezeichnung
- STAT5B (STAT5B Produkte)
- Synonyme
- STAT5 antikoerper, stat5 antikoerper, STAT5A antikoerper, STAT5B antikoerper, signal transducer and activator of transcription 5B antikoerper, signal transducer and activator of transcription 5B S homeolog antikoerper, Signal transducer and activator of transcription 5B antikoerper, STAT5B antikoerper, Stat5b antikoerper, stat5b.S antikoerper, LOC490969 antikoerper, sta5b antikoerper, LOC100566752 antikoerper, LOC100052954 antikoerper
- Hintergrund
- Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.
- Molekulargewicht
- 94kDa
- Gen-ID
- 6777
- UniProt
- P51692
- Pathways
- JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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