TIMP2 Antikörper (N-Term)

Produktnummer ABIN6940735

Produktdetails anti-TIMP2 Antikörper

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Bindungsspezifität: AA 56-66, N-Term

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Zebrafisch (Danio rerio), Kaninchen, Meerschweinchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Staining Methods (StM)

Spezifität: It recognizes a protein of 21 kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Aufreinigung: Purified by Protein A/G

Immunogen: A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)

Klon: 3A4

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.

Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Andere Bezeichnung: TIMP2 (TIMP2 Produkte)

Synonyme: CSC-21K antikoerper, DDC8 antikoerper, timp2l antikoerper, zgc:65967 antikoerper, zgc:85799 antikoerper, D11Bwg1104e antikoerper, Timp-2 antikoerper, TIMP-2 antikoerper, etID32613.12 antikoerper, fa96h09 antikoerper, timp2 antikoerper, wu:fa96h09 antikoerper, zgc:136726 antikoerper, TIMP metallopeptidase inhibitor 2 antikoerper, TIMP metallopeptidase inhibitor 2b antikoerper, tissue inhibitor of metalloproteinase 2 antikoerper, TIMP metallopeptidase inhibitor 2a antikoerper, TIMP metallopeptidase inhibitor 2 L homeolog antikoerper, TIMP2 antikoerper, timp2b antikoerper, Timp2 antikoerper, timp2a antikoerper, timp2.L antikoerper

Molekulargewicht: 21kDa

Gen-ID: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process