Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) Antikörper

Produktnummer ABIN6940807

Der Maus Monoklonal anti-Complement 3d (C3d) (Acute Humoral Rejection Marker) Antikörper (Klon C3D-2891) (ABIN6940807) detektiert spezifisch Complement 3d (C3d) (Acute Humoral Rejection Marker) in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) Antikörper (ABIN6940807)

Target: Complement 3d (C3d) (Acute Humoral Rejection Marker)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: C3D-2891

Produktdetails

Bindungsspezifität: AA 1250-1450

Verwendungszweck: Complement 3d (C3d) (Acute Humoral Rejection Marker) Antibody

Spezifität: The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1250-1450) of human C3 protein (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human kidney or rejected renal transplant tissue.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Antigendetails

Target: Complement 3d (C3d) (Acute Humoral Rejection Marker)

Hintergrund:

CPAMD1; Acylation stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment

Human liver cancer or rejected renal transplant tissue.

Molekulargewicht: 35kDa (predicted)

Gen-ID: 718, 529053

UniProt: P01024