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Rekombinanter Ubiquitin B Antikörper (AA 1-119)

UBB Reaktivität: Human IHC, StM Wirt: Kaninchen Monoclonal UBB-3143R unconjugated Recombinant Antibody
Produktnummer ABIN6940846
  • Target Alle Ubiquitin B (UBB) Antikörper anzeigen
    Ubiquitin B (UBB)
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-119
    Reaktivität
    • 41
    • 24
    • 18
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 35
    • 6
    Kaninchen
    Klonalität
    • 32
    • 9
    Monoklonal
    Konjugat
    • 24
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser Ubiquitin B Antikörper ist unkonjugiert
    Applikation
    • 21
    • 9
    • 9
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant fragment of human Ubiquitin protein (around aa 1-119) (exact sequence is proprietary)
    Klon
    UBB-3143R
    Isotyp
    IgG
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  • Applikationshinweise

    Positive Control: HeLa or Jurkat cells. Alzheimer's Brain.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    Ubiquitin B (UBB)
    Andere Bezeichnung
    UBB (UBB Produkte)
    Synonyme
    AL033289 antikoerper, Rps27a antikoerper, Uba52 antikoerper, Ubb2 antikoerper, Ubc antikoerper, UBC antikoerper, Ubiquitin antikoerper, UBB antikoerper, Ubi-p63E antikoerper, im:6892314 antikoerper, si:ch211-202a12.3 antikoerper, ubc antikoerper, zUBC antikoerper, zgc:172187 antikoerper, ubiquitin B antikoerper, ubiquitin C antikoerper, UBB antikoerper, Ubb antikoerper, UBC antikoerper, ubb antikoerper
    Hintergrund
    Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.
    Molekulargewicht
    9kDa
    Gen-ID
    7314
    UniProt
    P62979, P62987, P62988
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagie, EGFR Downregulation, Ubiquitin Proteasome Pathway
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