ACTN2 Antikörper (AA 557-692)

Produktnummer ABIN6940979

Produktdetails anti-ACTN2 Antikörper

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Bindungsspezifität: AA 557-692

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACTN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)

Aufreinigung: Purified by Protein A/G

Immunogen: A recombinant fragment (aa557-692) of human ACTN2 protein (exact sequence is proprietary)

Klon: ACTN2-3292

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Skeletal or Cardiac Muscle.

Known Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu ACTN2

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Andere Bezeichnung: ACTN2 (ACTN2 Produkte)

Synonyme: MGC89234 antikoerper, ACTN2 antikoerper, 1110008F24Rik antikoerper, CMD1AA antikoerper, wu:fd44c03 antikoerper, zgc:123223 antikoerper, actinin alpha 2 antikoerper, actinin, alpha 2b antikoerper, actinin alpha 2 S homeolog antikoerper, actn2 antikoerper, ACTN2 antikoerper, Actn2 antikoerper, actn2b antikoerper, actn2.S antikoerper

Hintergrund: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 103kDa

Gen-ID: 88

UniProt: P35609

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity