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CD74 Antikörper

CD74 Reaktivität: Human, Maus, Pavian FACS, IF, IHC, StM Wirt: Maus Monoclonal LN-2 unconjugated
Produktnummer ABIN6941253
  • Target Alle CD74 Antikörper anzeigen
    CD74 (HLA-DR-gamma (CD74))
    Reaktivität
    • 186
    • 70
    • 13
    • 10
    Human, Maus, Pavian
    Wirt
    • 119
    • 91
    • 4
    • 2
    Maus
    Klonalität
    • 134
    • 80
    • 2
    Monoklonal
    Konjugat
    • 69
    • 17
    • 16
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser CD74 Antikörper ist unkonjugiert
    Applikation
    • 123
    • 109
    • 75
    • 40
    • 37
    • 36
    • 29
    • 27
    • 17
    • 14
    • 13
    • 11
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    It recognizes a protein of ~35 kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
    Keine Kreuzreaktivität
    Ratte (Rattus)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    SU-DHL-4 lymphoma cells
    Klon
    LN-2
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD74 Primärantikörper
  • Applikationshinweise

    Positive Control: Daudi or Raji cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), (Methanol Fixed)Immunofluorescence (1-4 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    CD74 (HLA-DR-gamma (CD74))
    Andere Bezeichnung
    CD74 (CD74 Produkte)
    Synonyme
    DHLAG antikoerper, HLADG antikoerper, II antikoerper, Ia-GAMMA antikoerper, CLIP antikoerper, Ii antikoerper, INVG34 antikoerper, Iclp-1 antikoerper, iclp1 antikoerper, wu:fb11f09 antikoerper, wu:fb12a01 antikoerper, wu:fb13d06 antikoerper, wu:fk94e07 antikoerper, Iclp-2 antikoerper, cd74 antikoerper, iclp2 antikoerper, zgc:123161 antikoerper, CD74 molecule antikoerper, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain a antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain b antikoerper, CD74 antikoerper, Cd74 antikoerper, cd74a antikoerper, cd74b antikoerper
    Molekulargewicht
    33-41kDa
    Gen-ID
    972
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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