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Macrophage / Histiocytoma Marker Antikörper

Reaktivität: Human IHC, StM Wirt: Maus Monoclonal LN-5 unconjugated
Produktnummer ABIN6941347
  • Target Alle Macrophage / Histiocytoma Marker Produkte
    Macrophage / Histiocytoma Marker
    Reaktivität
    Human
    Wirt
    • 2
    Maus
    Klonalität
    • 2
    Monoklonal
    Konjugat
    • 2
    Dieser Macrophage / Histiocytoma Marker Antikörper ist unkonjugiert
    Applikation
    Immunohistochemistry (IHC), Staining Methods (StM)
    Immunogen
    Human peripheral blood mononuclear cells
    Klon
    LN-5
    Isotyp
    IgM kappa
  • Applikationshinweise

    Positive Control: Liver or histiocytoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    Macrophage / Histiocytoma Marker
    Andere Bezeichnung
    Macrophage, pan (Histiocytoma & Sebocyte Marker) (Macrophage / Histiocytoma Marker Produkte)
    Hintergrund
    This MAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer's cells of the liver and Langerhan's cells of the skin. Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and pro-monocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becoming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). LN-5 selectively stains human sebaceous glands in formalin-fixed, paraffin-embedded skin samples. Undifferentiated sebocyte progenitors are negative, and only sebocytes from the onset of their differentiation reveal positive cytoplasmic staining. Since there are very few selective and easy-to-use markers of sebaceous glands, LN-5 antibody can offer a simple and relatively specific way to detect human sebocytes from the onset of their.
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