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Rekombinanter MHC Class II HLA-DP/DQ/DR Antikörper

HLA-DP/DQ/DR Reaktivität: Human FACS, IF, WB, IHC, Coat, ELISA, StM Wirt: Kaninchen Monoclonal HLA-Pan-2967R unconjugated Recombinant Antibody
Produktnummer ABIN6941452
  • Target Alle MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR) Produkte
    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 21
    • 1
    Human
    Wirt
    • 20
    • 1
    Kaninchen
    Klonalität
    • 21
    Monoklonal
    Konjugat
    • 11
    • 4
    • 2
    • 2
    • 1
    • 1
    Dieser MHC Class II HLA-DP/DQ/DR Antikörper ist unkonjugiert
    Applikation
    • 19
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), Coating (Coat), ELISA, Staining Methods (StM)
    Spezifität
    Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Non-T, non-B human acute lymphoblastic leukemia REH6 cell line
    Klon
    HLA-Pan-2967R
    Isotyp
    IgG
  • Applikationshinweise

    Positive Control: Ramos or Raji cells. Tonsil or lymph node.

    Known Application: ELISA (For coating use Ab at 2-5 μg/mL, order Ab without BSA), Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL). Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
    Andere Bezeichnung
    HLA-DP, HLA-DQ, HLA-DR (HLA-DP/DQ/DR Produkte)
    Molekulargewicht
    33-35kDa
    Gen-ID
    3115, 3117, 3122
    UniProt
    P04440, P01908, P01909, P01920, P01903
    Pathways
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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