DIAPH1 Antikörper

Produktnummer ABIN6943002

Produktdetails anti-DIAPH1 Antikörper

Target: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser DIAPH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein corresponding to N-terminal human DIAPH1.

Klon: 1C11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu DIAPH1

Target: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Andere Bezeichnung: DIAPH1 (DIAPH1 Produkte)

Synonyme: DIAPH1 antikoerper, dia1 antikoerper, drf1 antikoerper, dfna1 antikoerper, diap1 antikoerper, lfhl1 antikoerper, DIAPH2 antikoerper, Diap1 antikoerper, D18Wsu154e antikoerper, Dia1 antikoerper, Diaph1 antikoerper, Drf1 antikoerper, mKIAA4062 antikoerper, p140mDia antikoerper, DFNA1 antikoerper, DIA1 antikoerper, DRF1 antikoerper, LFHL1 antikoerper, hDIA1 antikoerper, diaphanous related formin 1 antikoerper, diaphanous related formin 2 antikoerper, diaphanous-related formin 1 antikoerper, protein diaphanous homolog 1 antikoerper, DIAPH1 antikoerper, diaph1 antikoerper, DIAPH2 antikoerper, Diaph1 antikoerper, LOC100457442 antikoerper

Hintergrund:

Synonyms: Protein diaphanous homolog 1, Diaphanous-related formin-1, DRF1, DIAPH1, DIAP1

Background: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Plays a role in brain development. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.

Gen-ID: 1729

UniProt: O60610

Pathways: Sensory Perception of Sound