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IQSEC1 Antikörper (AA 451-550)

IQSEC1 Reaktivität: Maus WB, IF (cc), IF (p), ELISA, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6943528
  • Target Alle IQSEC1 Antikörper anzeigen
    IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
    Bindungsspezifität
    • 14
    • 3
    • 2
    • 1
    AA 451-550
    Reaktivität
    • 18
    • 5
    • 4
    Maus
    Wirt
    • 19
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IQSEC1 Antikörper ist unkonjugiert
    Applikation
    • 19
    • 12
    • 12
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GEP100
    Isotyp
    IgG
    Top Product
    Discover our top product IQSEC1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
    Andere Bezeichnung
    GEP100/IQSEC1 (IQSEC1 Produkte)
    Synonyme
    ARF-GEP100 antikoerper, ARFGEP100 antikoerper, BRAG2 antikoerper, GEP100 antikoerper, AW561907 antikoerper, BC026481 antikoerper, D6Ertd349e antikoerper, cI-43 antikoerper, mKIAA0763 antikoerper, IQ motif and Sec7 domain 1 antikoerper, IQSEC1 antikoerper, Iqsec1 antikoerper
    Hintergrund

    Synonyms: ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, ARF GEP100, ARFGEP100, BRAG2, Brefeldin A resistant ARF GEF2, Brefeldin-resistant Arf-GEF 2 protein, GEP100, IQ motif and Sec7 domain 1, IQ motif and SEC7 domain-containing protein 1, IQEC1_HUMAN, Iqsec1, Kiaa0763.

    Background: The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin 1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.

    Gen-ID
    9922
    UniProt
    Q6DN90
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