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MC1 Receptor Antikörper (AA 181-280) (Biotin)

MC1R Reaktivität: Human WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN6944036
  • Target Alle MC1 Receptor (MC1R) Antikörper anzeigen
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    Bindungsspezifität
    • 16
    • 14
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 181-280
    Reaktivität
    • 63
    • 27
    • 11
    • 4
    • 3
    • 1
    • 1
    Human
    Wirt
    • 65
    • 10
    Kaninchen
    Klonalität
    • 72
    • 3
    Polyklonal
    Konjugat
    • 29
    • 8
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MC1 Receptor Antikörper ist konjugiert mit Biotin
    Applikation
    • 51
    • 26
    • 26
    • 26
    • 14
    • 11
    • 8
    • 7
    • 6
    • 4
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MC1 Receptor
    Isotyp
    IgG
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  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    Andere Bezeichnung
    MC1 Receptor (MC1R Produkte)
    Synonyme
    CMM5 antikoerper, MSH-R antikoerper, SHEP2 antikoerper, Mshra antikoerper, Tob antikoerper, e antikoerper, MC1-R antikoerper, MSHR antikoerper, mc1r antikoerper, MC1R antikoerper, TUBB3 antikoerper, melanocortin 1 receptor antikoerper, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antikoerper, MC1R antikoerper, Mc1r antikoerper, mc1r antikoerper, mc1r_par1 antikoerper
    Hintergrund

    Synonyms: MC1 Receptor, CMM5, MC1-R, MC-1R, MC1R, Melanocortin 1 receptor, Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Melanotropin receptor, MSH-R, MSHR, MSHR_HUMAN, SHEP2.

    Background: This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

    Gen-ID
    4157
    UniProt
    Q01727
    Pathways
    cAMP Metabolic Process, Feeding Behaviour
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