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MUC4 Antikörper

MUC4 Reaktivität: Human, Ratte WB, IHC (p), FACS Wirt: Kaninchen Monoclonal 3A1 unconjugated
Produktnummer ABIN6944168
  • Target Alle MUC4 Antikörper anzeigen
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Reaktivität
    • 37
    • 12
    • 3
    Human, Ratte
    Wirt
    • 29
    • 9
    Kaninchen
    Klonalität
    • 22
    • 16
    Monoklonal
    Konjugat
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser MUC4 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    C terminal Human MUC4
    Klon
    3A1
    Isotyp
    IgG
    Top Product
    Discover our top product MUC4 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Andere Bezeichnung
    MUC4 (MUC4 Produkte)
    Synonyme
    4933405I11Rik antikoerper, Asgp antikoerper, ASGP antikoerper, HSA276359 antikoerper, MUC-4 antikoerper, ASGP-1 antikoerper, Psmc antikoerper, mucin 4 antikoerper, mucin 4, cell surface associated antikoerper, Muc4 antikoerper, MUC4 antikoerper
    Hintergrund

    Synonyms: Mucin-4, Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin-4 alpha chain, Ascites sialoglycoprotein 1, Mucin-4 beta chain, Ascites sialoglycoprotein 2, MUC-4, ASGP, ASGP-1, ASGP-2, MUC4

    Background: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

    Gen-ID
    4585
    UniProt
    Q99102
    Pathways
    Regulation of Leukocyte Mediated Immunity
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