RANGAP1 Antikörper

Produktnummer ABIN6944745

Produktdetails anti-RANGAP1 Antikörper

Target: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser RANGAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human RanGAP1 aa 1-200.

Klon: 2A1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RANGAP1

Target: RANGAP1 (Ran GTPase Activating Protein 1 (RANGAP1))

Andere Bezeichnung: RanGAP1 (RANGAP1 Produkte)

Synonyme: Fug1 antikoerper, RANGAP antikoerper, SD antikoerper, ATRANGAP1 antikoerper, RAN GTPASE-ACTIVATING PROTEIN 1 antikoerper, RAN GTPase activating protein 1 antikoerper, RanGAP1 antikoerper, fug1 antikoerper, rangap1b antikoerper, rna1p antikoerper, C79654 antikoerper, mKIAA1835 antikoerper, rangap1 antikoerper, rangap1a antikoerper, Protein rna1 antikoerper, CG9999 antikoerper, CT28175 antikoerper, Dmel\CG9999 antikoerper, RGP1_DROME antikoerper, Ran antikoerper, RanGAP antikoerper, RanGap antikoerper, RanGap1 antikoerper, Scl antikoerper, Sd antikoerper, Sd-RanGAP antikoerper, Sd-RanGap antikoerper, dRanGAP antikoerper, ranGAP antikoerper, ranGap antikoerper, rangap antikoerper, zgc:154097 antikoerper, Ran GTPase activating protein 1 antikoerper, RAN GTPase activating protein 1 antikoerper, ran GTPase activating protein 1 antikoerper, Ran GTPase activating protein 1 S homeolog antikoerper, Ran GTPase activating protein 1 L homeolog antikoerper, Ran GAP Rna1 antikoerper, Ran GTPase activating protein antikoerper, RAN GTPase activating protein 1a antikoerper, RANGAP1 antikoerper, TERG_02084 antikoerper, rangap1.S antikoerper, Rangap1 antikoerper, rangap1.L antikoerper, rna1 antikoerper, RanGAP antikoerper, rangap1a antikoerper

Hintergrund:

Synonyms: Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835

Background: The small Ras related protein Ran, also called TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). The abundant GEF RCC1 (regulator of chromosome condensation 1) increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.

Gen-ID: 5905

UniProt: P46060

Pathways: M Phase, Protein targeting to Nucleus