TET2 Antikörper

Produktnummer ABIN6945142

Produktdetails anti-TET2 Antikörper

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TET2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus

Aufreinigung: Protein G purified polyclonal antibody in PBS containing 0.05% azide

Immunogen: Monoclonal antibody raised in mouse against a recombinant protein containing the N-terminal 300 amino acids of human TET2 (tet oncogene family member 2).

Klon: 6A1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IP(1-2 μg)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: PBS with 0.05 % sodium azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Andere Bezeichnung: TET2 (TET2 Produkte)

Synonyme: KIAA1546 antikoerper, MDS antikoerper, Ayu17-449 antikoerper, E130014J05Rik antikoerper, mKIAA1546 antikoerper, RGD1311625 antikoerper, tet methylcytosine dioxygenase 2 antikoerper, TET2 antikoerper, Tet2 antikoerper

Hintergrund:

Synonyms: Methylcytosine dioxygenase TET2, TET2, KIAA1546

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Gen-ID: 54790

UniProt: Q6N021

Pathways: Warburg Effekt