XDH Antikörper

Produktnummer ABIN6945395

Produktdetails anti-XDH Antikörper

Target: XDH (Xanthine Dehydrogenase (XDH))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser XDH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human Xanthine Oxidase aa 100-300.

Klon: 2D9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu XDH

Target: XDH (Xanthine Dehydrogenase (XDH))

Andere Bezeichnung: Xanthine Oxidase (XDH Produkte)

Synonyme: XO antikoerper, XOR antikoerper, Xor antikoerper, Xox-1 antikoerper, Xox1 antikoerper, XDH antikoerper, im:7146167 antikoerper, DDBDRAFT_0219626 antikoerper, DDBDRAFT_0230176 antikoerper, DDB_0219626 antikoerper, DDB_0230176 antikoerper, xanthine dehydrogenase antikoerper, xanthine dehydrogenase/oxidase antikoerper, Xanthine dehydrogenase antikoerper, XDH antikoerper, Xdh antikoerper, xdh antikoerper, LOC576712 antikoerper, Trebr_1754 antikoerper

Hintergrund:

Synonyms: Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase, Xanthine oxidase, Xanthine oxidoreductase, XD, XO, XOR, XDH, XDHA

Background: The process of metabolizing purines to a common molecule known as xanthine is an essential process for the proper shuttling of uric acid. Xanthine oxidase is a flavoprotein enzyme that coordinates molybdenum and utilizes NAD+ as an electron acceptor to catalyze the oxidation of hypoxanthine to xanthine and then to uric acid. The predominant form of this enzyme is xanthine dehydrogenase, which is a homodimer that can be converted to xanthine oxidase by sulfhydryl oxidation or proteolytic modification. Xanthine oxidase is present in species ranging from bacteria to human and is ubiquitously expressed in mammalian tissues. In the oxidase form, this enzyme is coupled to the generation of free radicals. Individuals showing marked elevation of serum xanthine oxidase is suggestive of chronic liver disease and cholestasis, which is a condition defined by hepatic obstruction. Hepatic obstruction causes bile salts, the bile pigment bilirubin, and fats to accumulate in the blood stream instead of being eliminated normally. The clinical consequences of defects in xanthine oxidase range from mild to severe and even contribute to fatal disorders.

Gen-ID: 7498

UniProt: P47989

Pathways: Positive Regulation of Endopeptidase Activity