Rekombinanter SARS-CoV-2 Spike S1 Antikörper (FITC)
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- Target Alle SARS-CoV-2 Spike S1 Antikörper anzeigen
- SARS-CoV-2 Spike S1
- Antikörpertyp
- Recombinant Antibody
- Fragment
- scFv fragment
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Reaktivität
- SARS Coronavirus-2 (SARS-CoV-2)
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Wirt
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Human
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Klonalität
- Monoklonal
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Konjugat
- Dieser SARS-CoV-2 Spike S1 Antikörper ist konjugiert mit FITC
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Applikation
- ELISA
- Produktmerkmale
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Recombinant anti-SARS-CoV-2 spike Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
Mouse scFv fusion with human IgG1 Fc
AA 16-685 - Aufreinigung
- Affinity-chromatography
- Immunogen
- Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa)
- Klon
- H6
- Isotyp
- IgG1
- Top Product
- Discover our top product SARS-CoV-2 Spike S1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
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- Target
- SARS-CoV-2 Spike S1
- Abstract
- SARS-CoV-2 Spike S1 Produkte
- Synonyme
- E2 antikoerper, Surface Glycoprotein antikoerper, S antikoerper
- Substanzklasse
- Viral Protein
- Hintergrund
- Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.
- Gen-ID
- 43740568
- UniProt
- P0DTC2
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