IL12 Antikörper (Biotin)

Produktnummer ABIN6963864

Produktdetails anti-IL12 Antikörper (Biotin)

Target: IL12 (Interleukin 12 (IL12))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL12 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, ELISpot

Spezifität: IL-12 (p70)

Kreuzreaktivität (Details): The monoclonal antibody cross-reacts with IL-12 (p70) from non-human primates.

Produktmerkmale: This monoclonal antibody enables specific detection of human IL-12 (p70) in immunoassays such as ELISpot, FluoroSpot, and ELISA. Serum/Plasma samples

Aufreinigung: Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.,Purified from in vitro cultures by protein G affinity chromatography.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant human IL-12 p70

Klon: MT704

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

ABIN6963864 and ABIN7448307 is recommended as detection mAb in ELISpot, FluoroSpot, and ELISA in combination with capture mAbs .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Haltbarkeit: 18 months

Referenzen für anti-IL12 Antikörper (Biotin) (ABIN6963864)

Tomasicchio, Semple, Esmail, Meldau, Randall, Pooran, Davids, Cairncross, Anderson, Downs, Malherbe, Novitzky, Panieri, Oelofse, Londt, Naiker, Dheda: "An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells." in: Cancer immunology, immunotherapy : CII, Vol. 68, Issue 1, pp. 71-83, (2019) (PubMed).

Tootoonchian, Pak, Ardekani, Sehati, Abedi-Valugerdi, Kokhaei: "Evaluation of interleukin 12 and CD56+ lymphocyte cells in pediatric hematopoietic stem cell transplantation for early diagnosis of acute graft versus host disease." in: Transplant immunology, Vol. 39, pp. 25-29, (2018) (PubMed).

Tagawa, Albanese, Bouvet, Moosmann, Mautner, Heissmeyer, Zielinski, Lutter, Hoser, Hastreiter, Hayes, Sugden, Hammerschmidt: "Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing." in: The Journal of experimental medicine, Vol. 213, Issue 10, pp. 2065-80, (2017) (PubMed).

Zhang, Morgan, Beane, Zheng, Dudley, Kassim, Nahvi, Ngo, Sherry, Phan, Hughes, Kammula, Feldman, Toomey, Kerkar, Restifo, Yang, Rosenberg: "Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 10, pp. 2278-88, (2016) (PubMed).

Persson, Ekerfelt, Jablonowska, Jonsson, Ernerudh, Jenmalm, Berg: "Immunological status in patients undergoing in vitro fertilisation: responses to hormone treatment and relationship to outcome." in: Journal of reproductive immunology, Vol. 96, Issue 1-2, pp. 58-67, (2013) (PubMed).

Details zu IL12

Target: IL12 (Interleukin 12 (IL12))

Andere Bezeichnung: IL12 (p70) (IL12 Produkte)

Gen-ID: 3592, 3593

Pathways: JAK-STAT Signalweg, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome