Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Actin-Like 6B Antikörper (N-Term)

ACTL6B Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6971353
  • Target Alle Actin-Like 6B (ACTL6B) Antikörper anzeigen
    Actin-Like 6B (ACTL6B)
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 31
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 31
    • 1
    Kaninchen
    Klonalität
    • 31
    • 1
    Polyklonal
    Konjugat
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Actin-Like 6B Antikörper ist unkonjugiert
    Applikation
    • 25
    • 19
    • 16
    • 13
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Produktmerkmale
    ACTL6B (Actin-Like 6B) Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). ACTL6B antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
    Aufreinigung
    Affinity Purified
    Immunogen
    This antibody was raised against a peptide within the N-terminal region of human ACTL6B.
    Isotyp
    IgG
    Top Product
    Discover our top product ACTL6B Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    Actin-Like 6B (ACTL6B)
    Andere Bezeichnung
    ACTL6B (ACTL6B Produkte)
    Synonyme
    MGC110167 antikoerper, zgc:110167 antikoerper, ACTL6 antikoerper, BAF53B antikoerper, Actl6 antikoerper, ArpNa antikoerper, Baf53b antikoerper, actin-like 6B antikoerper, actin like 6B antikoerper, actl6b antikoerper, ACTL6B antikoerper, Actl6b antikoerper
    Molekulargewicht
    50 kDa
    NCBI Accession
    NP_057272
Sie sind hier:
Kundenservice