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BAZ2A Antikörper (N-Term)

BAZ2A Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6971425
  • Target Alle BAZ2A Antikörper anzeigen
    BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
    Bindungsspezifität
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    Human
    Wirt
    • 17
    • 1
    Kaninchen
    Klonalität
    • 18
    Polyklonal
    Konjugat
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BAZ2A Antikörper ist unkonjugiert
    Applikation
    • 8
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A) is an essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). BAZ2A antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunofluorescence and Western blot, it has been shown to react with Human samples.
    Aufreinigung
    Affinity Purified
    Immunogen
    This antibody was raised against a peptide within the N-terminal region of human BAZ2A.
    Isotyp
    IgG
    Top Product
    Discover our top product BAZ2A Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
    Andere Bezeichnung
    BAZ2A (BAZ2A Produkte)
    Synonyme
    zgc:101601 antikoerper, tip5 antikoerper, bax2a antikoerper, walp3 antikoerper, TIP5 antikoerper, WALp3 antikoerper, AA415431 antikoerper, C030005G16Rik antikoerper, C78388 antikoerper, Tip5 antikoerper, Walp3 antikoerper, mKIAA0314 antikoerper, bromodomain adjacent to zinc finger domain, 2A antikoerper, bromodomain adjacent to zinc finger domain 2A antikoerper, bromodomain adjacent to zinc finger domain 2A L homeolog antikoerper, Baz2a antikoerper, baz2a antikoerper, BAZ2A antikoerper, baz2a.L antikoerper
    Molekulargewicht
    270 kDa
    NCBI Accession
    NP_038477
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