DDB1 Antikörper (C-Term)

Produktnummer ABIN6971574

Produktdetails anti-DDB1 Antikörper

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: DDB1 (DNA damage-binding protein 1, HBV X-associated protein 1, XAP-1, Xeroderma pigmentosum group E-complementing protein) is a DNA binding protein that associates with DNA following UV damage and functions in excision repair. In addition to its function in DNA repair, DDB1 plays a role in normal mitotic exit by regulating Anaphase Promoting Complex (APC) activity. Depletion of DDB1 in mitotic cells significantly delays mitotic exit. DDB1 facilitates the binding of substrates to the Cul4-Roc1 complex and the ubiquitination of selected proteins, including histones H2A, H3 and H4 localized to the sites of DNA damage. It is also involved in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of P53 in response to radiation-induced DNA damage and during DNA replication. In mouse studies, it was identified that loss of DDB1 function prevents hepatocytes from replicating DNA, inducing compensatory proliferation of normal hepatocytes that leads to development of hepatocellular carcinoma. DDB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This DDB1 antibody was raised against a peptide from the C-terminus of human DDB1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu DDB1

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Andere Bezeichnung: DDB1 (DDB1 Produkte)

Synonyme: DDBA antikoerper, UV-DDB1 antikoerper, XAP1 antikoerper, XPCE antikoerper, XPE antikoerper, XPE-BF antikoerper, DDB1 antikoerper, xpe antikoerper, ddba antikoerper, xap1 antikoerper, xpce antikoerper, xpe-bf antikoerper, uv-ddb1 antikoerper, ddb1 antikoerper, 127kDa antikoerper, AA408517 antikoerper, p127-Ddb1 antikoerper, damage specific DNA binding protein 1 antikoerper, damage-specific DNA binding protein 1, 127kDa antikoerper, DNA damage-binding protein 1 antikoerper, damage-specific DNA binding protein 1 antikoerper, DDB1 antikoerper, ddb1 antikoerper, LOC100187356 antikoerper, Ddb1 antikoerper, ddb-1 antikoerper

Molekulargewicht: 140 kDa

NCBI Accession: NP_001914

Pathways: DNA Reparatur