DMAP1 Antikörper (C-Term)

Produktnummer ABIN6971584

Produktdetails anti-DMAP1 Antikörper

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktmerkmale: DMAP1 (DNA Methyltransferase 1 Associated Protein 1) is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. DMAP1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a peptide within the C-terminal region of human DMAP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu DMAP1

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Andere Bezeichnung: DMAP1 (DMAP1 Produkte)

Synonyme: Afu4g07380 antikoerper, T8I13.5 antikoerper, DNMAP1 antikoerper, DNMTAP1 antikoerper, EAF2 antikoerper, MEAF2 antikoerper, SWC4 antikoerper, zgc:55593 antikoerper, dnmap1 antikoerper, dnmtap1 antikoerper, eaf2 antikoerper, meaf2 antikoerper, swc4 antikoerper, 1500016M21Rik antikoerper, Dmtap1 antikoerper, mKIAA1425 antikoerper, DNA methyltransferase 1-associated protein DMAP1 antikoerper, DNA methyltransferase 1-associated protein 1 antikoerper, DNA methyltransferase 1 associated protein 1 antikoerper, myb-like transcription factor family protein antikoerper, DNA methyltransferase 1 associated protein 1 L homeolog antikoerper, AFUA_4G07380 antikoerper, NFIA_108840 antikoerper, ACLA_046700 antikoerper, CpipJ_CPIJ017959 antikoerper, Bm1_47540 antikoerper, PMAA_026820 antikoerper, AFLA_112450 antikoerper, TSTA_072020 antikoerper, BDBG_02603 antikoerper, AT2G47210 antikoerper, CpipJ_CPIJ007438 antikoerper, DMAP1 antikoerper, dmap1 antikoerper, dmap1.L antikoerper, Dmap1 antikoerper

Molekulargewicht: 60 kDa

NCBI Accession: NP_061973