DOT1L Antikörper (C-Term)

Produktnummer ABIN6971602

Produktdetails anti-DOT1L Antikörper

Target: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOT1L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: DOT1L (Disruptor of Telomeric silencing 1-like, also known as KMT4) is the mammalian homologue of the yeast Dot1 protein and the Drosophila Grappa protein. DOTL1 is the enzyme responsible for lysine 79 methylation of histone H3. DOT1L can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia, thus leading to aberrant methylation of lysine 79 at MLL target genes. In contrast to most other histone lysine methyltransferases, DOT1L does not contain a SET domain. Biochemical studies suggest that recombinant DOT1L is active on recombinant nucleosomes. DOT1L antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This DOT1L antibody was raised against a peptide derived from the C-terminal region of human DOT1L.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu DOT1L

Target: DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))

Andere Bezeichnung: DOT1L (DOT1L Produkte)

Synonyme: NV11307 antikoerper, DOT1L antikoerper, DOT1 antikoerper, KMT4 antikoerper, A630076O07 antikoerper, AW907654 antikoerper, Dot1 antikoerper, mDot1 antikoerper, histone-lysine N-methyltransferase, H3 lysine-79 specific antikoerper, DOT1 like histone lysine methyltransferase antikoerper, histone methyltransferase antikoerper, DOT1-like, histone H3 methyltransferase (S. cerevisiae) antikoerper, LOC100116648 antikoerper, DOT1L antikoerper, DOT1 antikoerper, Dot1l antikoerper

Molekulargewicht: 200 kDa

NCBI Accession: NP_115871