MLL5/KMT2E Antikörper

Produktnummer ABIN6972268

Produktdetails anti-MLL5/KMT2E Antikörper

Target: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLL5/KMT2E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: KMT2E (MLL5) (myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila / lysine N-methyltransferase 2E)) is a histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. KMT2E (MLL5) antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human and Mouse samples.

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a peptide within human KMT2E (MLL5).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu MLL5/KMT2E

Target: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Andere Bezeichnung: KMT2E (MLL5) (MLL5 Produkte)

Synonyme: HDCMC04P antikoerper, MLL5 antikoerper, 1810033J14Rik antikoerper, 9530077A04Rik antikoerper, D230038D11Rik antikoerper, Mll5 antikoerper, lysine methyltransferase 2E antikoerper, lysine (K)-specific methyltransferase 2E antikoerper, KMT2E antikoerper, Kmt2e antikoerper

Molekulargewicht: 85 kDa

NCBI Accession: NP_891847

Pathways: Retinoic Acid Receptor Signaling Pathway, Warburg Effekt