SATB1 Antikörper (N-Term)

Produktnummer ABIN6972695

Produktdetails anti-SATB1 Antikörper

Target: SATB1 (SATB Homeobox 1 (SATB1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SATB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: SATB1 (Special AT-rich sequence-binding protein 1) is a chromosome-associated protein that binds to matrix attachment regions (MARs) of DNA at special AT-rich sequences and induces local chromatin-loop remodeling. SATB1 functions as both a chromatin organizer and transcription factor. It regulates gene expression and higher-order chromatin structure of multigene clusters. SATB1 acts as a docking site for several chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. It is required for the switching of fetal globin genes, plays a role in chromatin organization and nuclear architecture during apoptosis. It is a crucial factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis. SATB1 contributes to metastatic potential in breast cancer cells, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. It is also required for the differentiation of embryonic stem cells through repression of ES pluripotency factors Nanog, Klf4, and Tbx3. SATB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human and Mouse samples.

Aufreinigung: Affinity Purified

Immunogen: This SATB1 antibody was raised against a peptide within the N-terminal region of SATB1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu SATB1

Target: SATB1 (SATB Homeobox 1 (SATB1))

Andere Bezeichnung: SATB1 (SATB1 Produkte)

Synonyme: 2610306G12Rik antikoerper, AW413156 antikoerper, SATB1 antikoerper, sb:cb955 antikoerper, si:ch211-195k18.2 antikoerper, SATB homeobox 1 antikoerper, special AT-rich sequence binding protein 1 antikoerper, SATB homeobox 1a antikoerper, SATB1 antikoerper, Satb1 antikoerper, satb1 antikoerper, satb1a antikoerper

Molekulargewicht: 105 kDa

NCBI Accession: NP_001124482

Pathways: Caspase Kaskade in der Apoptose, Activated T Cell Proliferation