SUPT16H Antikörper

Produktnummer ABIN6972824

Produktdetails anti-SUPT16H Antikörper

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUPT16H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Supt16H / Supt16 (suppressor of Ty 16 homolog (S. cerevisiae)) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Supt16H / Spt16 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a synthetic peptide containing human Supt16H / Spt16.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu SUPT16H

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Andere Bezeichnung: Supt16H / Spt16 (SUPT16H Produkte)

Synonyme: CDC68 antikoerper, FACTP140 antikoerper, SPT16/CDC68 antikoerper, CG1828 antikoerper, DRE4/dSPT16 antikoerper, Dmel\\CG1828 antikoerper, SPT16 antikoerper, Spt16 antikoerper, dSPT16 antikoerper, dSpt16 antikoerper, dspt16 antikoerper, l(3)62Bg antikoerper, l(3)dre4 antikoerper, spt16 antikoerper, Cdc68 antikoerper, Fact140 antikoerper, Supt16h antikoerper, T12H20.3 antikoerper, T12H20_3 antikoerper, global transcription factor C antikoerper, SSF1 antikoerper, DDBDRAFT_0204912 antikoerper, DDBDRAFT_0231753 antikoerper, DDB_0204912 antikoerper, DDB_0231753 antikoerper, DUF140 antikoerper, SPT16 homolog, facilitates chromatin remodeling subunit antikoerper, FACT complex subunit spt16 antikoerper, FACT complex subunit SPT16 antikoerper, CG1828 gene product from transcript CG1828-RB antikoerper, suppressor of Ty 16 antikoerper, global transcription factor C antikoerper, chromatin-remodeling protein SPT16 antikoerper, FACT complex component Spt16 antikoerper, chromatin-remodeling protein antikoerper, global regulator of transcription antikoerper, FACT (FAcilitates Chromatin Transcription) complex subunit, putative antikoerper, SPT16 homolog, facilitates chromatin remodeling subunit S homeolog antikoerper, SUPT16H antikoerper, AOR_1_1808194 antikoerper, CC1G_05155 antikoerper, dre4 antikoerper, Supt16 antikoerper, SPT16 antikoerper, spt16 antikoerper, CDC68 antikoerper, Supt16h antikoerper, supt16h antikoerper, supt16h.S antikoerper

Molekulargewicht: 140 kDa

NCBI Accession: NP_009123

Pathways: Chromatin Binding