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VRK2 Antikörper (AA 151-250) (AbBy Fluor® 350)

VRK2 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN6976477
  • Target Alle VRK2 Antikörper anzeigen
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 151-250
    Reaktivität
    • 32
    • 20
    • 1
    Maus
    Wirt
    • 45
    • 2
    • 1
    Kaninchen
    Klonalität
    • 47
    • 1
    Polyklonal
    Konjugat
    • 16
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser VRK2 Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 38
    • 25
    • 12
    • 12
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human VRK2
    Isotyp
    IgG
    Top Product
    Discover our top product VRK2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Andere Bezeichnung
    VRK2 (VRK2 Produkte)
    Synonyme
    2810003O05Rik antikoerper, AI447698 antikoerper, vaccinia related kinase 2 antikoerper, VRK2 antikoerper, Vrk2 antikoerper
    Hintergrund

    Synonyms: Serine/threonine-protein kinase VRK2, VRK2, Vaccinia-related kinase 2

    Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

    Gen-ID
    7444
    UniProt
    Q86Y07
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