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Importin 5 Antikörper (AA 501-600) (Biotin)

IPO5 Reaktivität: Ratte ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN6982634
  • Target Alle Importin 5 (IPO5) Antikörper anzeigen
    Importin 5 (IPO5)
    Bindungsspezifität
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-600
    Reaktivität
    • 27
    • 25
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 37
    • 4
    Kaninchen
    Klonalität
    • 39
    • 2
    Polyklonal
    Konjugat
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Importin 5 Antikörper ist konjugiert mit Biotin
    Applikation
    • 13
    • 13
    • 12
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Karyopherin beta 3
    Isotyp
    IgG
    Top Product
    Discover our top product IPO5 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    Importin 5 (IPO5)
    Andere Bezeichnung
    Karyopherin beta 3 (IPO5 Produkte)
    Synonyme
    IPO5 antikoerper, RANBP5 antikoerper, IMB3 antikoerper, KPNB3 antikoerper, Pse1 antikoerper, imp5 antikoerper, 1110011C18Rik antikoerper, 5730478E03Rik antikoerper, AA409333 antikoerper, C76941 antikoerper, Kpnb3 antikoerper, Ranbp5 antikoerper, importin 5 antikoerper, IPO5 antikoerper, Ipo5 antikoerper
    Hintergrund

    Synonyms: DKFZp686O1576, FLJ43041, IMB3, Imp5, Importin 5, Importin beta 3 subunit, Importin subunit beta 3, Importin subunit beta-3, Importin-5, IPO 5, IPO5, IPO5_HUMAN, Karyopherin beta 3, Karyopherin beta-3, KPNB3, MGC2068, Pse1, Ran binding protein 5, Ran GTP binding protein 5, Ran-binding protein 5, RanBP 5, RanBP5.

    Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

    Gen-ID
    3843
    UniProt
    O00410
    Pathways
    Protein targeting to Nucleus
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