DTX3L Antikörper (AA 651-740) (Cy3)

Produktnummer ABIN6983342

Produktdetails anti-DTX3L Antikörper (Cy3)

Target: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Bindungsspezifität: AA 651-740

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTX3L Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DTX3L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DTX3L

Target: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Andere Bezeichnung: DTX3L (DTX3L Produkte)

Synonyme: BBAP antikoerper, RGD1565144 antikoerper, AU042200 antikoerper, BC023741 antikoerper, DTX3L antikoerper, deltex E3 ubiquitin ligase 3L antikoerper, deltex 3-like, E3 ubiquitin ligase antikoerper, probable E3 ubiquitin-protein ligase DTX3 antikoerper, DTX3L antikoerper, Dtx3l antikoerper, LOC100521724 antikoerper

Hintergrund:

Synonyms: BBAP, E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L

Background: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Gen-ID: 151636

UniProt: Q8TDB6

Pathways: Notch Signalweg