DTX3L Antikörper (AA 651-740) (FITC)
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- Target Alle DTX3L Antikörper anzeigen
- DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
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Bindungsspezifität
- AA 651-740
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DTX3L Antikörper ist konjugiert mit FITC
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Homologie
- Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DTX3L
- Isotyp
- IgG
- Top Product
- Discover our top product DTX3L Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
- Andere Bezeichnung
- DTX3L (DTX3L Produkte)
- Synonyme
- BBAP antikoerper, RGD1565144 antikoerper, AU042200 antikoerper, BC023741 antikoerper, DTX3L antikoerper, deltex E3 ubiquitin ligase 3L antikoerper, deltex 3-like, E3 ubiquitin ligase antikoerper, probable E3 ubiquitin-protein ligase DTX3 antikoerper, DTX3L antikoerper, Dtx3l antikoerper, LOC100521724 antikoerper
- Hintergrund
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Synonyms: BBAP, E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L
Background: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
- Gen-ID
- 151636
- UniProt
- Q8TDB6
- Pathways
- Notch Signalweg
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