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PSME3 Antikörper (AA 181-254)

PSME3 Reaktivität: Ratte IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6988996
  • Target Alle PSME3 Antikörper anzeigen
    PSME3
    Bindungsspezifität
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 181-254
    Reaktivität
    • 47
    • 21
    • 17
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Ratte
    Wirt
    • 42
    • 7
    Kaninchen
    Klonalität
    • 44
    • 5
    Polyklonal
    Konjugat
    • 31
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PSME3 Antikörper ist unkonjugiert
    Applikation
    • 36
    • 18
    • 15
    • 8
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PSME3
    Isotyp
    IgG
    Top Product
    Discover our top product PSME3 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PSME3
    Andere Bezeichnung
    PSME3 (PSME3 Produkte)
    Synonyme
    AA410043 antikoerper, AU020960 antikoerper, Ki antikoerper, PA28gamma antikoerper, REGgamma antikoerper, pa28g antikoerper, Ab2-371 antikoerper, PA28-gamma antikoerper, PA28G antikoerper, REG-GAMMA antikoerper, psme3b antikoerper, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antikoerper, proteasome activator subunit 3 antikoerper, proteasome activator subunit 3 S homeolog antikoerper, Psme3 antikoerper, PSME3 antikoerper, psme3.S antikoerper
    Hintergrund

    Synonyms: PA28G, 11S regulator complex gamma subunit, 11S regulator complex subunit gamma, Activator of multicatalytic protease subunit 3, Ki antibody Ki antigen, Ki nuclear autoantigen, Ki, PA28 gamma, PA28 gamma, PA28gamma, Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki), Proteasome (prosome, macropain) activator subunit 3, Proteasome activator 28 gamma, Proteasome activator 28 subunit gamma, Proteasome activator complex subunit 3, Proteasome activator subunit 3, PSME3, PSME3_HUMAN,

    Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

    Gen-ID
    10197
    UniProt
    P61289
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
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