TTC3 Antikörper (AA 251-350)

Produktnummer ABIN6989022

Produktdetails anti-TTC3 Antikörper

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Bindungsspezifität: AA 251-350

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTC3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus, Ratte

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RNF105

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TTC3

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Andere Bezeichnung: RNF105 (TTC3 Produkte)

Synonyme: DCRR1 antikoerper, RNF105 antikoerper, TPRDIII antikoerper, 2610202A04Rik antikoerper, AA409221 antikoerper, D16Ium21 antikoerper, D16Ium21e antikoerper, TPRD antikoerper, mKIAA4119 antikoerper, TTC3 antikoerper, tetratricopeptide repeat domain 3 antikoerper, E3 ubiquitin-protein ligase TTC3 antikoerper, TTC3 antikoerper, Ttc3 antikoerper, LOC100562480 antikoerper

Hintergrund:

Synonyms: DCRR1, E3 ubiquitin protein ligase TTC3, E3 ubiquitin-protein ligase TTC3, Protein DCRR1, RING finger protein 105,Tetratricopeptide repeat protein 3 (TPR repeat protein D), Tetratricopeptide repeat protein 3, TPR repeat protein 3, TPR repeat protein D, TPRD, TPRDI, TPRDII, TPRDIII, TTC3, TTC3_HUMAN.

Background: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

Gen-ID: 7267

UniProt: P53804