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PPM1D Antikörper

PPM1D Reaktivität: Human, Maus, Ratte IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6989347
  • Target Alle PPM1D Antikörper anzeigen
    PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
    Reaktivität
    • 54
    • 12
    • 10
    • 1
    Human, Maus, Ratte
    Wirt
    • 51
    • 3
    Kaninchen
    Klonalität
    • 51
    • 3
    Polyklonal
    Konjugat
    • 18
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPM1D Antikörper ist unkonjugiert
    Applikation
    • 44
    • 27
    • 13
    • 8
    • 4
    • 2
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PPM1D:471-570/605
    Isotyp
    IgG
    Top Product
    Discover our top product PPM1D Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
    Andere Bezeichnung
    PPM1D (PPM1D Produkte)
    Synonyme
    PP2C-DELTA antikoerper, WIP1 antikoerper, AV338790 antikoerper, Wip1 antikoerper, zgc:103518 antikoerper, ppm1d antikoerper, wu:fj44c08 antikoerper, zgc:55836 antikoerper, zgc:77316 antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1D antikoerper, protein phosphatase 1D magnesium-dependent, delta isoform antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1D antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antikoerper, PPM1D antikoerper, Ppm1d antikoerper, ppm1db antikoerper, ppm1d.L antikoerper, ppm1da antikoerper
    Hintergrund

    Synonyms: WPP-DOMAIN INTERACTING PROTEIN 1, EC 3.1.3.16, p53 induced protein phosphatase 1, PP2C delta, PP2CD, protein phosphatase 1D magnesium-dependent delta isoform, Protein phosphatase 2C delta isoform, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium dependent 1 delta, WIP 1, WIP1, AV338790, PPM1D_HUMAN.

    Background: PPM1D (Wip) is a serine/threonine phosphatase implicated in cell cycle control, spermatogenesis, and lymphoid cell function. The predicted 605-amino acid PPM1D protein contains 2 putative nuclear localization signals and 3 regions conserved in serine/threonine PP2C phosphatases, as well as characteristics of a type 2C phosphatase, including magnesium dependence and relative insensitivity to okadaic acid. PPM1D expression is induced in response to ionizing radiation in a p53-dependent manner. The accumulation of PPM1D mRNA following ionizing radiation is rapid and transient, and PPM1D protein is localized to the nucleus. PPM1D may contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. PPM1D inhibits phosphorylation of the p38 mitogen-activated (MAP)kinase protein. Through p38 MAPK, PPM1D modulates the CDKN2A tumor-suppressor locus. This gene is located in a chromosomal region known to be amplified in breast cancer, (located at 17q22-q23), is amplified in human breast tumor cell lines and in approximately 11 % of primary breast tumors, and appears to lead to cell transformation by abrogating p53 tumor suppressor activity. Inactivation of the p38 MAPK through PPM1D overexpression resulting from PPM1D amplification may contributes to the development of human cancers by suppressing p53 activation. PPM1D null mice have increased susceptibility to pathogens and reduced male fertility and longevity. Function : Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Subunit : Interacts with CHEK1 and CHEK2, dephosphorylates them. Similarity : Belongs to the PP2C family. Contains 1 PP2C-like domain.

    Gen-ID
    8493
    UniProt
    O15297
    Pathways
    p53 Signalweg, Zellzyklus
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