MPRIP Antikörper (C-Term)

Produktnummer ABIN6990325

Produktdetails anti-MPRIP Antikörper

Target: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MPRIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: RIP3 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-RIP3 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.1-0.5 μ,g/mL, IHC-P: 5 μ,g/mL, IF: 20 μ,g/mL, IP: 20 μ,g/mL.

Antibody validated: Western Blot in mouse and human samples, Immunohistochemistry in mouse and rat samples, Immunofluorescence in mouse and rat samples, Immunoprecipitation in human samples, Immunogold EM in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: RIP3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: RIP3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Referenzen für anti-MPRIP Antikörper (ABIN6990325)

Wu, Chung, Cao, Jin, Edmiston, Hickman, Levy, Whalen, Abrams, Degterev, Lo, Tozzi, Kaplan, El Khoury, Whalen: "Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis." in: Cell death & disease, Vol. 12, Issue 11, pp. 1064, (2021) (PubMed).

Details zu MPRIP

Target: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Andere Bezeichnung: RIP3 (MPRIP Produkte)

Synonyme: M-RIP antikoerper, MRIP antikoerper, RHOIP3 antikoerper, RIP3 antikoerper, p116Rip antikoerper, 9530046C02 antikoerper, AA536749 antikoerper, AI647711 antikoerper, C76423 antikoerper, Rhoip3 antikoerper, mKIAA0864 antikoerper, M-rip antikoerper, Mrip antikoerper, myosin phosphatase Rho interacting protein antikoerper, MPRIP antikoerper, Mprip antikoerper

Hintergrund: RIP3 Antibody: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-κ,B activation. Overexpression of RIP3 induces apoptosis and NF-κ,B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.

Molekulargewicht: Predicted: 53kD for mouse RIP3 and 57kD for human RIP3

Observed: 53kD for mouse RIP3 and 57kD for human RIP3 kDa

Gen-ID: 56532

UniProt: Q9QZL0