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BIRC2 Antikörper (C-Term)

BIRC2 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990458
  • Target Alle BIRC2 Antikörper anzeigen
    BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
    Bindungsspezifität
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    AA 540-590, C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 39
    • 4
    Kaninchen
    Klonalität
    • 39
    • 4
    Polyklonal
    Konjugat
    • 17
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BIRC2 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 21
    • 21
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    cIAP Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-cIAP antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human cIAP. c-IAP antibody detects both c-IAP1 and c-IAP2. The immunogen is located within amino acids 540-590 of cIAP.
    Isotyp
    IgG
    Top Product
    Discover our top product BIRC2 Primärantikörper
  • Applikationshinweise
    WB: 1-4 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    cIAP Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    cIAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
    Andere Bezeichnung
    cIAP (BIRC2 Produkte)
    Synonyme
    API1 antikoerper, HIAP2 antikoerper, Hiap-2 antikoerper, MIHB antikoerper, RNF48 antikoerper, c-IAP1 antikoerper, cIAP1 antikoerper, Api2 antikoerper, rIAP1 antikoerper, IAP1 antikoerper, ITA antikoerper, AW146227 antikoerper, Api1 antikoerper, Birc3 antikoerper, HIAP1 antikoerper, IAP2 antikoerper, MIAP1 antikoerper, MIAP2 antikoerper, MIHC antikoerper, cIAP2 antikoerper, mcIAP1 antikoerper, ciap-1 antikoerper, birc3 antikoerper, api1 antikoerper, birc2 antikoerper, c-iap1 antikoerper, ciap1 antikoerper, hiap-2 antikoerper, hiap2 antikoerper, mihb antikoerper, rnf48 antikoerper, baculoviral IAP repeat containing 2 antikoerper, baculoviral IAP repeat-containing 2 antikoerper, baculoviral IAP repeat containing 2 L homeolog antikoerper, BIRC2 antikoerper, Birc2 antikoerper, birc2 antikoerper, birc2.L antikoerper
    Hintergrund
    CIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α, by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
    Molekulargewicht
    Predicted: 70kD

    Observed: 70kD kDa
    Gen-ID
    329
    NCBI Accession
    NP_001157
    UniProt
    Q13490
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades
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