BIRC6 Antikörper (C-Term)

Produktnummer ABIN6990463

Produktdetails anti-BIRC6 Antikörper

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Bindungsspezifität: AA 4760-4810, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.

Aufreinigung: BRUCE Antibody is affinity chromatography purified via peptide column.

Immunogen: BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BRUCE Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BIRC6

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Andere Bezeichnung: BRUCE (BIRC6 Produkte)

Synonyme: APOLLON antikoerper, BRUCE antikoerper, bruce antikoerper, apollon antikoerper, BIRC6 antikoerper, A430032G04Rik antikoerper, A430040A19Rik antikoerper, AA501170 antikoerper, Bruce antikoerper, D630005A10Rik antikoerper, mKIAA1289 antikoerper, baculoviral IAP repeat containing 6 antikoerper, baculoviral IAP repeat-containing 6 antikoerper, BIRC6 antikoerper, Birc6 antikoerper, birc6 antikoerper

Hintergrund: BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Molekulargewicht: 534 kDa

Gen-ID: 57448

NCBI Accession: NP_057336

UniProt: Q9NR09