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SIGIRR Antikörper (C-Term)

SIGIRR Reaktivität: Human, Maus WB, ICC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990481
  • Target Alle SIGIRR Antikörper anzeigen
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Bindungsspezifität
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    C-Term
    Reaktivität
    • 21
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 24
    • 4
    • 1
    Kaninchen
    Klonalität
    • 24
    • 5
    Polyklonal
    Konjugat
    • 21
    • 6
    • 2
    Dieser SIGIRR Antikörper ist unkonjugiert
    Applikation
    • 27
    • 14
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), ELISA
    Aufreinigung
    SIGIRR Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.
    Isotyp
    IgG
    Top Product
    Discover our top product SIGIRR Primärantikörper
  • Applikationshinweise
    SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    SIGIRR Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Andere Bezeichnung
    SIGIRR (SIGIRR Produkte)
    Synonyme
    TIR8 antikoerper, AI256711 antikoerper, sc:d148 antikoerper, RGD1306732 antikoerper, single Ig and TIR domain containing antikoerper, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antikoerper, SIGIRR antikoerper, Sigirr antikoerper, sigirr antikoerper
    Hintergrund
    SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.
    Molekulargewicht
    Predicted: 45 kDa

    Observed: 45 kDa 
    Gen-ID
    59307
    UniProt
    Q6IA17
    Pathways
    Toll-Like Receptors Cascades
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