SIGIRR Antikörper (C-Term)

Produktnummer ABIN6990481

Produktdetails anti-SIGIRR Antikörper

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGIRR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), ELISA

Aufreinigung: SIGIRR Antibody is affinity chromatography purified via peptide column.

Immunogen: SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SIGIRR Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SIGIRR

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Andere Bezeichnung: SIGIRR (SIGIRR Produkte)

Synonyme: TIR8 antikoerper, AI256711 antikoerper, sc:d148 antikoerper, RGD1306732 antikoerper, single Ig and TIR domain containing antikoerper, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antikoerper, SIGIRR antikoerper, Sigirr antikoerper, sigirr antikoerper

Hintergrund: SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Molekulargewicht: Predicted: 45 kDa

Observed: 45 kDa 

Gen-ID: 59307

UniProt: Q6IA17

Pathways: Toll-Like Receptors Cascades