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TAB2 Antikörper (C-Term)

TAB2 Reaktivität: Human ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990488
  • Target Alle TAB2 Antikörper anzeigen
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Bindungsspezifität
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reaktivität
    • 17
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 15
    • 4
    Kaninchen
    Klonalität
    • 17
    • 2
    Polyklonal
    Konjugat
    • 19
    Dieser TAB2 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
    Aufreinigung
    TAB2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. The immunogen is located within the last 50 amino acids of TAB2.
    Isotyp
    IgG
    Top Product
    Discover our top product TAB2 Primärantikörper
  • Applikationshinweise
    TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    TAB2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    TAB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Andere Bezeichnung
    TAB2 (TAB2 Produkte)
    Synonyme
    CHTD2 antikoerper, MAP3K7IP2 antikoerper, 1110030N06Rik antikoerper, A530078N03Rik antikoerper, Map3k7ip2 antikoerper, mKIAA0733 antikoerper, map3k7ip2 antikoerper, zgc:77446 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antikoerper, TAB2 antikoerper, Tab2 antikoerper, tab2 antikoerper
    Hintergrund
    TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
    Gen-ID
    23118
    NCBI Accession
    NP_055908
    UniProt
    Q9NYJ8
    Pathways
    T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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