TAB2 Antikörper (C-Term)
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- Target Alle TAB2 Antikörper anzeigen
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TAB2 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
- Aufreinigung
- TAB2 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. The immunogen is located within the last 50 amino acids of TAB2.
- Isotyp
- IgG
- Top Product
- Discover our top product TAB2 Primärantikörper
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- Applikationshinweise
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TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μ,g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- TAB2 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,4 °C
- Informationen zur Lagerung
- TAB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
- Andere Bezeichnung
- TAB2 (TAB2 Produkte)
- Synonyme
- CHTD2 antikoerper, MAP3K7IP2 antikoerper, 1110030N06Rik antikoerper, A530078N03Rik antikoerper, Map3k7ip2 antikoerper, mKIAA0733 antikoerper, map3k7ip2 antikoerper, zgc:77446 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antikoerper, TAB2 antikoerper, Tab2 antikoerper, tab2 antikoerper
- Hintergrund
- TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
- Gen-ID
- 23118
- NCBI Accession
- NP_055908
- UniProt
- Q9NYJ8
- Pathways
- T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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