Caspase 4 Antikörper (N-Term)

Produktnummer ABIN6990514

Produktdetails anti-Caspase 4 Antikörper

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Bindungsspezifität: AA 20-70, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: Depending on cell lines or tissues used, other cleavage products may be observed.

Aufreinigung: Caspase-4 Antibody is affinity chromatography purified via peptide column.

Immunogen: Caspase-4 antibody was raised against a 16 amino acid synthetic peptide from the amino-terminus of human Caspase-4. The immunogen is located within amino acids 20 - 70 of Caspase-4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Casp-4 antibody can be used for the detection of Caspase-4 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Caspase-4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Caspase-4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Caspase 4

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Andere Bezeichnung: Caspase-4 (CASP4 Produkte)

Synonyme: ICE(rel)II antikoerper, ICEREL-II antikoerper, ICH-2 antikoerper, Mih1/TX antikoerper, TX antikoerper, Casp11 antikoerper, CASP13 antikoerper, CASP1 antikoerper, CASP4 antikoerper, Caspl antikoerper, ich-3 antikoerper, Casp4 antikoerper, caspase 4 antikoerper, caspase 4, apoptosis-related cysteine peptidase antikoerper, caspase-4 antikoerper, CASP4 antikoerper, Casp4 antikoerper, LOC100731032 antikoerper

Hintergrund: Caspase-4 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β, and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease.

Gen-ID: 837

UniProt: P49662

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity