Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PTRH2 Antikörper (N-Term)

PTRH2 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990569
  • Target Alle PTRH2 Antikörper anzeigen
    PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
    Bindungsspezifität
    • 13
    • 11
    • 10
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-70, N-Term
    Reaktivität
    • 60
    • 14
    • 13
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 59
    • 1
    Kaninchen
    Klonalität
    • 60
    Polyklonal
    Konjugat
    • 22
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser PTRH2 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 26
    • 19
    • 9
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Aufreinigung
    Bit1 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Bit1 antibody was raised against a 15 amino acid synthetic peptide from near the amino-terminus of human Bit1. The immunogen is located within amino acids 20 - 70 of Bit1.
    Isotyp
    IgG
    Top Product
    Discover our top product PTRH2 Primärantikörper
  • Applikationshinweise
    Bit1 antibody can be used for the detection of Bit1 by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Bit1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    Bit1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
    Andere Bezeichnung
    Bit1 (PTRH2 Produkte)
    Synonyme
    BIT1 antikoerper, PTH2 antikoerper, A230072I16Rik antikoerper, Bit1 antikoerper, CGI-147 antikoerper, wu:fj09f02 antikoerper, zgc:109954 antikoerper, RGD1306819 antikoerper, peptidyl-tRNA hydrolase 2 antikoerper, ptrh2 antikoerper, CC1G_10259 antikoerper, ANI_1_1036184 antikoerper, AOR_1_2082154 antikoerper, PTRH2 antikoerper, Ptrh2 antikoerper
    Hintergrund
    Bit1 Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apoptosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE. Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
    Gen-ID
    51651
    NCBI Accession
    NP_057161
    UniProt
    Q9Y3E5
Sie sind hier:
Kundenservice